Duromine and liver
Multiple clinical trials show us that Duromine (Phentermine) can affect the central nervous system, gastrointestinal tract and cardiovascular system. However, there has been established no connection between the use of Duromine and change in the liver functions.
A small part of active substance Phentermine is known to be metabolized in the liver. The main part of Phentermine (up to 85%) is excreted unchanged in urine within 72 hours after the application of Duromine single dose.
Overweight people with healthy liver do not require dose adjustment of Duromine. Patients with severe liver disease are recommended to take minimal doses of Duromine – 15mg or 30mg.
Duromine (Phentermine) causes toxic effect on the liver, but only in overdose. Therefore, the daily Duromine dose must never exceed 40mg (one Duromine 40mg capsule, once daily), regardless of the obesity severity. Even if a patient misses a dose of Duromine 40mg, he must never double the dose of this weight loss drug.
In addition, it is not recommended to take Duromine capsules in the evening. When used before bedtime, toxic effect of Duromine on the liver increases. Besides, the application of Duromine weight loss pills in late afternoon may cause sleep disorder and even insomnia.
It is very important to refrain from alcohol drinks during therapy with Duromine. Alcohol affects functions of the liver and increases the toxic effect of Duromine on it.
Considering that Duromine pills can cause severe side effects, they are sold at Australian pharmacies on prescription only. Before buying Duromine in Australia, obese patient should undergo a medical examination.